A randomized, placebo-controlled, double-blinded, crossover trial of pioglitazone for severe asthma.

Capsule SummaryThe PPAR-γ agonist, pioglitazone, was associated with significant side effects and did not improve the primary outcome measure of the Juniper Asthma Quality of Life Questionnaire (AQLQ) score in severe asthmatics. We conclude that no further studies should be performed with pioglitazone for severe asthma.