Novel adenovirus encoded virus-like particles displaying the placental malaria associated VAR2CSA antigen.

Anne-Marie C Andersson,Mafalda Resende,Ali Salanti,Morten A Nielsen,Peter J Holst

Vaccine（2017）

引用 11|浏览16

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摘要

•Anchoring of ID1-ID2a to virus-encoded VLPs improves functional antibody responses.•Virus-encoded VLP anchored ID1-ID2a efficiently primes ID1-ID2a protein boosts.•Antibody binding specificities are increased by ID1-ID2a VLP anchoring using HA TM-CT.

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关键词

Placental malaria,Adenoviral vectors,Prime-boost regimens,Virus-like particles,VAR2CSA

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