Calibration and performance of synchronous SIM/scan mode for simultaneous targeted and discovery (non-targeted) analysis of exhaled breath samples from firefighters.

•A SIM/Scan method was developed to evaluate target and non-target compounds.•Calibrated the SIM/scan method for eight VOC and eight PAH standards.•Utilized a new dual PAH/VOC standard loading method onto thermal desorption tubes.•Thirty-six firefighter samples were analyzed in SIM/scan mode.•Non-target compounds of interest to exposure were discovered in the scan chromatograms.