Identification and characterization of a new dapoxetine impurity by NMR: Transformation of N-oxide by Cope elimination.

Journal of Pharmaceutical and Biomedical Analysis（2017）

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摘要

•A novel dapoxetine impurity has been identified using IR, NMR and MS.•The mechanism for the impurity formation was proposed and confirmed by synthesis and degradation studies.•The synthesis of dapoxetine-N-oxide was completed for the first time.

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关键词

Priligy,Impurity profiling,Drug analysis geometric (E/Z) isomer,Degradation product,Metabolism,Hofmann elimination

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