In vitro assessment of anti-tumorigenic mechanisms and efficacy of NanoALA, a nanoformulation of aminolevulic acid designed for photodynamic therapy of cancer

Laise Rodrigues de Andrade,Fernando Lucas Primo,Jaqueline Rodrigues da Silva,Antonio Claudio Tedesco,Zulmira Guerrero Marques Lacava

Photodiagnosis and Photodynamic Therapy（2017）

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摘要

•Aminolevulic acid-loaded nanocapsules (NanoALA) are stable over a period of 90days.•NanoALA promotes greater ALA uptake than the free ALA.•The therapeutic efficacy is above 80% with only 1h incubation with the prodrug.•NanoALA needs shorter exposure times and lower concentration than the free ALA.

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关键词

Aminolevulic-acid (ALA),Photodynamic therapy (PDT),Nanocarriers,Poly(lactide-co-glycolide) (PLGA),Mammary carcinoma

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