Mesoderm/mesenchyme homeobox gene l promotes vascular smooth muscle cell phenotypic modulation and vascular remodeling.

Bing Wu,Lei Zhang,Yun-He Zhu,You-En Zhang,Fei Zheng,Jian-Ye Yang,Ling-Yun Guo,Xing-Yuan Li,Lu Wang,Jun-Ming Tang,Shi-You Chen,Jia-Ning Wang

International Journal of Cardiology（2018）

引用 23|浏览18

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摘要

Our data indicated that Meox1 promotes SMCs phenotypic modulation and injury-induced vascular remodeling by regulating the FAK-ERK1/2-autophagy signaling cascade. Thus, targeting Meox1 may be an attractive approach for treating proliferating vascular diseases.

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关键词

Mesoderm/mesenchyme homeobox gene l,Vascular smooth muscle cells,Phenotypic modulation,Vascular remodeling

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