Macrovipecetin, a C-type lectin from Macrovipera lebetina venom, inhibits proliferation migration and invasion of SK-MEL-28 human melanoma cells and enhances their sensitivity to cisplatin.

Manel B Hammouda,Ichrak Riahi-Chebbi,Soumaya Souid,Houcemeddine Othman,Zohra Aloui,Najet Srairi-Abid,Habib Karoui,Ammar Gasmi,Edith M Magnenat,Timothy N C Wells,Kenneth J Clemetson,José Neptuno Rodríguez-López,Khadija Essafi-Benkhadir

Biochimica et Biophysica Acta (BBA) - General Subjects（2018）

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摘要

•macrovipecetin is a novel heterodimeric C-type lectin from Macrovipera lebetina•macrovipecetin enhances the sensitivity of SK-MEL-28 cells to cisplatin by augmenting their apoptosis•macrovipecetin-cisplatin affects SK-MEL-28 cell adhesion via αvβ3 integrin•The interaction of macrovipecetin with the αvβ3 integrin involves the α chain.•Macrovipecetin-cisplatin affects SK-MEL-28 cell migration and invasion

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关键词

Macrovipecetin,Snaclec,Cisplatin efficacy,Melanoma,Anti-tumoral effect,Mechanistic characterization

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