Plasma metabolite profiles, cellular cholesterol efflux, and non-traditional cardiovascular risk in patients with CKD

Anjali Ganda,Laurent Yvan-Charvet,Yuan Zhang, Eric J. Lai,Renu Regunathan-Shenk,Farah N. Hussain,Rupali Avasare,Bibhas Chakraborty, Annie J. Febus, Linda Vernocchi,Rafael Lantigua,Ying Wang,Xu Shi,Joanne Hsieh,Andrew J. Murphy,Nan Wang,Nora Bijl,Kristie M. Gordon, Maria Hamm de Miguel,Jessica R. Singer

Journal of Molecular and Cellular Cardiology（2017）

引用 30|浏览5

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摘要

•Cholesterol efflux in humans varies in terms of cellular components.•We report a cellular defect in ABCA1-mediated cholesterol efflux in CKD patients.•Plasma metabolites predicted cardiovascular events in CKD patients.

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关键词

Atherosclerosis,Immunology,Kidney,Metabolomics,Risk factors

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