Prevalence, determinants and clinical correlates of vitamin D deficiency in patients with Chronic Obstructive Pulmonary Disease in London, UK.

David A Jolliffe,Wai Yee James,Richard L Hooper,Neil C Barnes,Claire L Greiller,Kamrul Islam,Angshu Bhowmik,Peter M Timms,Raj K Rajakulasingam,Aklak B Choudhury,David E Simcock,Elina Hyppönen,Robert T Walton,Christopher J Corrigan,Christopher J Griffiths,Adrian R Martineau

The Journal of Steroid Biochemistry and Molecular Biology（2018）

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摘要

•Vitamin D deficiency is common among UK adults with chronic obstructive pulmonary disease.•Classical environmental determinants of vitamin D status operate in this population.•Vitamin D status associated with clinical markers of lung function.•Genetic variation in the vitamin D pathway did not influence vitamin D status or measures of COPD severity.

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关键词

Vitamin D,COPD,Single nucleotide polymorphism,Spirometry,FEV1,FVC

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