Ruthenium-Clotrimazole complex has significant efficacy in the murine model of cutaneous leishmaniasis

Eva Iniguez,Armando Varela-Ramirez,Alberto Martínez, Caresse L. Torres, Roberto A. Sánchez-Delgado,Rosa A. Maldonado

Acta Tropica（2016）

引用 16|浏览8

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摘要

•Metal compounds and its synergistic activity against cutaneous leishmaniasis.•Ru-CTZ compounds exert a mitochondrial dependent apoptotic-like death in L. major promastigotes.•Therapeutic efficacy in vivo of AM162 in the mouse model of cutaneous leishmaniasis.•A new candidate to compose AM162-derived analogs and new chemical formulations.

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关键词

Apoptosis,Cutaneous leishmaniasis,Drug discovery,Leishmania major,Parasites,Ruthenium-clotrimazole complex

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