Preclinical uPAR-targeted multimodal imaging of locoregional oral cancer.

•Novel tumour-specific multimodal imaging agent that will aid in surgical procedures.•Recognizing both neoplastic as well as tumour surrounding stromal cells.•Antibody-based, providing large imaging windows and high specific signals.•One administration sufficient for pre-, intra- and postoperative imaging.•The agent can be applied in low doses and visualizes millimetre sized metastases.