Tiger frog virus ORF080L protein interacts with LITAF and impairs EGF-induced EGFR degradation.

Yong-Shun Chen,Nan-Nan Chen,Xiao-Wei Qin,Shu Mi,Jian He,Yi-Fan Lin,Ming-Shi Gao,Shao-Ping Weng,Chang-Jun Guo,Jian-Guo He

Virus Research（2016）

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摘要

•Tiger frog virus (TFV) ORF080L is a late gene that encodes viral structural protein.•Silencing TFV ORF080L caused a decrease in viral replication.•TFV ORF080L interacted with LITAF and impaired EGF-induced EGFR degradation.

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关键词

Endosome-lysosome pathway,Iridovirus,LITAF,Tiger frog virus,Viral replication

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