Characterization of equine GST A3-3 as a steroid isomerase.

Helena Lindström, Shawna M Peer,Nancy H Ing,Bengt Mannervik

The Journal of Steroid Biochemistry and Molecular Biology（2018）

引用 14|浏览4

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摘要

•Glutathione transferase A3-3 (GST A3-3) effects steroid double-bond isomerizations.•Horse GST A3-3 is highly proficient with testosterone and progesterone precursors.•The enzyme is the most efficient steroid double-bond isomerase known in mammals.•Steroids provide higher catalytic efficiencies than conventional GST substrates.•Ovary, testis and adrenal gland express the highest GST A3-3 levels in the horse.

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关键词

Steroidogenesis,Horse testis,Catalytic efficiency glutathione transferase A3-3,Androstenedione,Pregnenedione

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