Whole-genome and Transcriptome Sequencing of Prostate Cancer Identify New Genetic Alterations Driving Disease Progression.

European Urology（2018）

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摘要

We presented the first comprehensive genetic alteration landscape of prostate cancer in Chinese men and identify novel genes and progression pathways that may help advance prostate cancer diagnosis, prognosis, and personalized medicine.

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关键词

Chinese prostate cancer,Whole genome sequencing,RNA-seq,CHD1 deletion,TMPRSS2-ERG fusion,AR coactivator mutation,Clustered deleted tumor suppressor genes,Axon guidance pathway,Prognosis,Personalized medicine

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