Identification of an Imidazopyridine Scaffold to Generate Potent and Selective TYK2 Inhibitors That Demonstrate Activity in an in Vivo Psoriasis Model. Jun Liang , Anne Van Abbema , Mercedesz Balazs , Kathy Barrett , Leo Berezhkovsky , Wade S. Blair , Christine Chang , Donnie Delarosa , Jason DeVoss , Jim Driscoll , Charles Eigenbrot , Simon Goodacre , Nico Ghilardi , Calum MacLeod , Adam Johnson , Pawan Bir Kohli , Yingjie Lai , Zhonghua Lin , Priscilla Mantik , Kapil Menghrajani , Hieu Nguyen , Ivan Peng , Amy Sambrone , Steven Shia , Jan Smith , Sue Sohn , Vickie Tsui , Mark Ultsch , Karen Williams , Lawren C. Wu , Wenqian Yang , Birong Zhang , Steven Magnuson Bioorganic & Medicinal Chemistry Letters（2017）
关键词
TYK2, Kinase, Psoriasis, Imidazopyridine, IL-23
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