Efficient Hepatitis C Virus Genotype 1b Core-NS5A Recombinants Permit Efficacy Testing of Protease and NS5A Inhibitors

    Antimicrobial agents and chemotherapy, Volume 61, Issue 6, 2017.

    Cited by: 6|Bibtex|Views1|Links
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    Keywords:
    HCVantiviral agentsantiviral susceptibility testingcell culturedirect-acting antiviralsMore(3+)

    Abstract:

    Hepatitis C virus (HCV) strains belong to seven genotypes with numerous subtypes that respond differently to antiviral therapies. Genotype 1, and primarily subtype 1b, is the most prevalent genotype worldwide. The development of recombinant HCV infectious cell culture systems for different variants, permitted by the high replication capac...More

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