Cytotoxic T-lymphocyte-associated protein 4-Ig effectively controls immune activation and inflammatory disease in a novel murine model of leaky severe combined immunodeficiency.

Stéphanie Humblet-Baron,Susann Schönefeldt,Josselyn E Garcia-Perez,Frédéric Baron,Emanuela Pasciuto,Adrian Liston

Journal of Allergy and Clinical Immunology（2017）

引用 5|浏览13

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摘要

These data suggest that cytotoxic T-lymphocyte-associated protein 4-Ig should be evaluated as a potential treatment of inflammatory symptoms in patients with LS and those with OS.

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关键词

Leaky severe combined immunodeficiency,Artemis,regulatory T cell,cytotoxic T-lymphocyte-associated protein 4,immune dysregulation

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