Prolonged stimulation of a brainstem raphe region attenuates experimental autoimmune encephalomyelitis.

•We proposed that brainstem activity can reverse experimental autoimmune encephalomyelitis, a model of multiple sclerosis.•The nucleus raphe magnus of the mouse’s hindbrain was wirelessly stimulated for up to several weeks.•The stimulation reduced overt symptoms and lastingly increased myelination.•After stimulation, immune cell invasion and some inflammatory cytokines were lower for at least several days.•These findings confirm the restorative role for raphe nuclei suggested by prior studies of neurotrauma.