Capture-Based Targeted Ultradeep Sequencing in Paired Tissue and Plasma Samples Demonstrates Differential Subclonal ctDNA-Releasing Capability in Advanced Lung Cancer.
Journal of Thoracic Oncology(2017)
摘要
We have demonstrated that subclones carrying driver mutations are more prone to release DNA. We have also demonstrated the quantitative ability of capture-based sequencing, paving its way for routine utilization in clinical settings.
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关键词
Lung cancer,Capture-based targeted sequencing,ctDNA,Liquid biopsy,Releasing capability
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