Effect of the novel synthetic cannabinoids AKB48 and 5F-AKB48 on "tetrad", sensorimotor, neurological and neurochemical responses in mice. In vitro and in vivo pharmacological studies.

Isabella Canazza,Andrea Ossato,Claudio Trapella,Anna Fantinati,Maria Antonietta De Luca,Giulia Margiani,Fabrizio Vincenzi,Claudia Rimondo,Fabiana Di Rosa,Adolfo Gregori,Katia Varani,Pier Andrea Borea,Giovanni Serpelloni,Matteo Marti

Psychopharmacology（2016）

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摘要

For the first time, the present study demonstrates the overall pharmacological effects induced by the administration of AKB48 and 5F-AKB48 in mice and suggests that the fluorination can increase the power and/or effectiveness of SCBs. Furthermore, this study outlines the potential detrimental effects of SCBs on human health.

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关键词

5F-AKB48,AKB48,Behavior,Cannabinoids,JWH-018,Microdialysis,Sensorimotor responses,Synthetic cannabinoids,Δ9-THC

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