IL-33 Promotes Food Anaphylaxis in Epicutaneously-Sensitized Mice By Targeting Mast Cells

Claire Galand,Juan-Manuel Leyva-Castillo,Raif S. Geha,Juhan Yoon,Michiko K. Oyoshi,Alex Han,Andrew McKenzie,Michael Stassen

Journal of Allergy and Clinical Immunology（2016）

引用 153|浏览9

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摘要

IL-33 is released after mechanical skin injury, enhances IgE-mediated MC degranulation, and promotes oral anaphylaxis after epicutaneous sensitization by targeting MCs. IL-33 neutralization might be useful in treating food-induced anaphylaxis in patients with AD.

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关键词

IL-33,ST2,food allergy,atopic dermatitis,mast cells

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