Optimization of macaque brain DMRI connectome by neuron tracing and myelin stain data.
Computerized Medical Imaging and Graphics(2018)
摘要
(a) Joint statistic matrix color-coded by TPs, FPs, FNs and TNs, which were obtained from the comparison between the connective matrices derived from tract-tracing database and dMRI data. The FVE brain map, the optimal brain map (out of the three brain maps in the present work) for global connectome, was used to construct connective matrices. The dMRI tractography connective matrix was constructed under the optimal tractography parameters (QA=0.2, Angle=70°) and binarized by the connective strength threshold corresponding to the maximal Youden index. Those parameters also apply to (b)–(i); (b) dMRI tractography fibers corresponding to the TP connections in (a). Fibers corresponding to the same connection have the same color; (c) The connective matrix color-coded by the average local C values on the dMRI fiber tracts corresponding to the TP connections. Pink block highlights those connecting brain sites in frontal lobe; (d) Top 1% connections in term of their large average local C values. Color blocks highlight some of these connections, and (e)-(i) show the corresponding dMRI fibers as well as the brain sites they connect. Dashed blocks indicate that those connections can find their symmetry counterparts in regions the solid blocks highlight. Interpretations of those blocks are found in the text.
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关键词
Tract-tracing,Myelin stain,dMRI,Multi-Scale and multi-modal fusion,Connectome
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