Towards Standardization of Medical Trials Using Virtual Experimenters

We describe a system for experiment standardization and distributing medication in medical trials using a virtual human. In our system, we employed a virtual experimenter that explains the experiment, medication, procedure and risks involved through a large screen display. The participant is able to interact with and ask questions of the virtual experimenter through a touch screen interface on an additional monitor display. During the interaction, the virtual experimenter will present the participant with a pill. The pill is physically distributed by a custom-made Arduino based dispenser. We conducted an initial user evaluation of the system using a placebo response protocol and a perceived pain scale. In the study, participants submerged their hand in a hot water bath before and after interacting with the system and reported their perceived pain response. The system was either a virtual human or text interface that either disseminated a pill stating that it was an analgesic or did not provide a medication. Through this system, we propose the potential use of virtual humans as a method to provide a consistent and standardized interaction between a participant and experimenter, while maintaining the benefits of social interaction in medication trials.