Filtering Invalid Off-Targets in CRISPR/Cas9 Design Tools

Ondrej Cvacho,Jan Holub

2018 Data Compression Conference（2018）

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摘要

The paper deals with an approximate string matching in CRISPR/Cas9 design tools. The approximate string matching is transformed into sequence of exact string matching tasks processed by fast succinct (compressed) self-index. The number of the tasks is rapidly decreased by filtering technique based on de Bruijn graph.

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关键词

Approximate string matching,Data compression,Data structures,Indexes

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