Erratum to: “DNA sequence-specific ligands: XVI. Series of the DBP( n ) fluorescent dimeric bisbenzimidazoles with 1,4-piperazine-containing linkers”

Russian Journal of Bioorganic Chemistry(2018)

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摘要
novel series of the DBP ( n ) fluorescent symmetric dimeric bisbenzimidazoles in which the bisbenzimidazole fragments were attached to an oligomeric linker with the 1,4-piperazine residue in its center were prepared. The DBP ( n ) molecules were distinguished by the number of methylene groups n (where n = 1, 2, 3, 4) in the linker. The DBP ( n ) synthesis was based on a condensation of the monomeric bisbenzimidazole (MB) with 1,4-piperazinedialkylcarbonic acids. The ability of the DBP ( n ) dimeric bisbenzimidazoles to form complexes with the double-stranded DNA was demonstrated by a complex of physicochemical methods, including spectroscopy in the visual UV-area, circular dichroism (CD), and fluorescence. The DBP(1–4) molecules were localized in the DNA minor groove by the CD method with the use of cholesteric liquid-crystalline dispersions (CLCD) of the double-stranded DNA. The DBP ( n ) dimeric bisbenzimidazoles were easily soluble in water, penetrated through cellular and nuclear membranes, and stained DNA in living cells distinct from the previously synthesized DB(n) series.
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关键词
dimeric bisbenzimidazole,DBP(,n,),complexes with the double-stranded DNA,DNA,minorgroove binder,fluorescence,circular dichroism
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