Tandem radical cyclization for the construction of 1-difluoroalkylated isoquinolines via Cu catalyzed and visible light-promoted pathways

A Cu/B(2)pin(2) system promoted cyclization for the synthesis of 1-difluoroalkylated isoquinolines with vinyl isocyanides and bromodifluoroacetic derivatives in moderate to good yields was reported. This method provided a mild and efficient pathway for the construction of diverse 1-difluoroalkylated isoquinolines via a proposed tandem radical cyclization process.