Effects of resveratrol on memory performance, hippocampus connectivity and microstructure in older adults – A randomized controlled trial

•In this randomized clinical trial, 6 months resveratrol supplementation showed no significant effects on verbal memory compared to placebo.•Unfavorable changes in lifestyle factors at follow-up might have introduced confounding.•Secondary analyses showed a trend towards preserved pattern recognition.•We used multimodal ultra high field MRI to detect subtle changes in microstructure of hippocampus subfields.