A ternary complex model of Sirtuin4-NAD+-Glutamate dehydrogenase

Yusuke Kato,Hiroshi Kihara,Kiyoshi Fukui,Masaki Kojima

Computational Biology and Chemistry（2018）

引用 7|浏览26

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摘要

•Homology models of Sitruin4 were built and evaluated.•A Sirtuin4 model complexed with NAD+ and glutamate dehydrogenase was built.•Acetylated Lys171 of glutamate dehydrogenase and NAD+ were close to each other.•These suggest the mechanism of ADP-ribosylation of glutamate dehydrogenase.

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关键词

GDH,GDH 158–187,NAD,RMSD,RMSF,Sir2,Sirt

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