An ontology-driven clinical decision support system (IDDAP) for infectious disease diagnosis and antibiotic prescription

•A decision support system (DSS) is proposed for assisting in prescription of antibiotics at the point of primary care.•The DSS adopts a patient-centered, step-wise decision support system using subjective judgment of the patients.•Based on the re-use of existing biomedical ontologies, a complete and large domain ontology is constructed.•DSS can fully utilize the infectious disease and antibiotics information for the diagnosis classification.