Prostaglandin D2 signaling mediated by the CRTH2 receptor is involved in MK-801-induced cognitive dysfunction

Yusuke Onaka,Norihito Shintani,Takanobu Nakazawa,Takuya Kanoh,Yukio Ago,Toshio Matsuda,Ryota Hashimoto,Kazutaka Ohi,Hiroyuki Hirai,Kin-ya Nagata,Masataka Nakamura,Atsushi Kasai,Atsuko Hayata-Takano,Kazuki Nagayasu,Kazuhiro Takuma,Asao Ogawa,Akemichi Baba,Hitoshi Hashimoto

Behavioural Brain Research（2016）

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摘要

•Genetic deletion of CRTH2 suppressed MK-801-induced cognitive dysfunction.•Inhibition of CRTH2 by ramatroban suppressed MK-801-induced cognitive dysfunction.•Inhibition of COX-1 by SC-560 suppressed MK-801-induced cognitive dysfunction.•MK-801-induced increase in c-Fos expression in the PVN was abolished in CRTH2−/− mice.•PGD2-CRTH2 signaling is involved in MK-801-induced cognitive dysfunction.

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关键词

CRTH2,COX,LPS,NMDA,NORT,PVN,PC/RS,PG,SNP,PFC

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