Docosahexaenoic acid (DHA) enhances the therapeutic potential of neonatal neural stem cell transplantation post—Traumatic brain injury

Hussein Ghazale,Naify Ramadan,Sara Mantash,Kazem Zibara, Sally El-Sitt,Hala Darwish,Farah Chamaa,Rose Mary Boustany,Stefania Mondello,Wassim Abou-Kheir,Jihane Soueid,Firas Kobeissy

Behavioural Brain Research（2018）

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摘要

•NSC transplantation coupled with DHA injections enhance motor recovery three weeks post mild TBI.•Endogenous neurogenesis is significantly enhanced after NSC transplantation coupled with DHA injections post mild-TBI.•NSC transplantation coupled with DHA injections increase glial reactivity and microglia post mild-TBI.•NSC transplantation coupled with DHA reduceTBI- induced dopaminergic neurons depletion in the midbrain.

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关键词

Traumatic brain injury,Neural stem cells,Docosahexaenoic acid,Neurogenesis,Reactive gliosis,Motor function

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