Why should neuroscientists worry about iron? The emerging role of ferroptosis in the pathophysiology of neuroprogressive diseases

Gerwyn Morris,Michael Berk,André F. Carvalho,Michael Maes,Adam J. Walker,Basant K. Puri

Behavioural Brain Research（2018）

引用 108|浏览34

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摘要

•Ferroptosis is a major driver of cell death in neurodegenerative diseases e.g. AD.•Oxidative and nitrosative stress adversely affect cellular iron homeostasis.•Ferroptosis entails membrane lipid peroxidation and mitochondria involvement.•Neuroinflammation and high NTBI levels make neuroglia sensitive to iron overload.•Deferiprone with N-acetylcysteine offers a rational therapeutic approach.

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ACSL4,AD,ARE,ANT,AP-1,ATP,Bak,BCEC,CNS,CoQ10,cPLA2,CREB,DFO,DFP,DFX,DHN,DMT-1,Fe-S,GSH,GPx4,GR,GSSG,HHE,HNA,HNE,HSP27,IMM,IRE,IRP,IL-6,Keap1,LOX,LPOs,MDA,MFRN1,MFRN2,MRI,NAC,NADPH,NOX,Nrf-2,NTBI,PD,PIC,PUFA,RNS,ROS,SLC25A28,SLC25A37,SOD,STAT-3,tBid,TCA,TNF-α,VDAC-1,Xc-,YY-1

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