Biochemical and cognitive effects of docosahexaenoic acid differ in a developmental and SorLA dependent manner

Anne Højland,Mette Richner,Simon Mølgaard, Ruthe Storgaard Dieu,Amanda Eskelund,Anders Nykjær,Jens Randel Nyengaard,Jens Lykkesfeldt,Simon Glerup,Morten Schallburg Nielsen

Behavioural Brain Research（2018）

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摘要

•Dietary omega-3 supplementation/deprivation effect requires lifelong exposure.•Lifelong DHA exposure reduces spatial learning and memory in SorLA deficient mice.•Reduced antioxidant capacity of vitamin C in brains of SorLA deficient mice.

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Ω3,Ω6,ADHD,DHA,GSH,GSSG,LpL,PUFA,Sorl1−/−

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