Hippocampal Aβ expression, but not phosphorylated tau, predicts cognitive deficits following repeated peripheral poly I:C administration

•7, 14, and 21 days of poly I:C administration increase hippocampal Aβ.•14, but not 7 or 21, days of poly I:C administration increases tau phosphorylation.•14 and 21 days of poly I:C administration lead to cognitive deficits.•Soluble Aβ levels, but not phosphorylated tau, predict cognitive deficits.