Analysis of in vitro demineralised human enamel using multi-scale correlative optical and scanning electron microscopy, and high-resolution synchrotron wide-angle X-ray scattering

•Highest sub-micron spatial resolution achieved for ultrastructure mapping in dental tissues over a large thickness.•Enamel microstructure revealed in etched and healthy enamel using SEM and FIB-SEM.•Preferential loss in Ca content compared to P from chemical analysis after acid etching.•Correlation between X-ray diffraction texture analysis and the dimension of the enamel structure.