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The distribution of the alpha7 nicotinic acetylcholine receptor in healthy aging: An in vivo positron emission tomography study with [F]ASEM.

Jennifer M Coughlin,Yong Du,Hailey B Rosenthal,Stephanie Slania, Soo Min Koo,Andrew Park,Ghedem Solomon,Melin Vranesic,Inga Antonsdottir,Caroline L Speck,Kelly Rootes-Murdy,Alexandria Lerner,Steven P Rowe,Yuchuan Wang,Wojciech G Lesniak,Il Minn,Arnold Bakker,Gwenn S Smith,Robert F Dannals,Hiroto Kuwabara,Andrew Horti,Dean F Wong,Martin G Pomper

NeuroImage（2018）

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摘要
Altered function of the alpha7 nicotinic acetylcholine receptor (α7-nAChR) is implicated in several neuropsychiatric diseases. Nevertheless, studies of the human cerebral α7-nAChR even in healthy aging are limited in number and to postmortem tissue.
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关键词
[18F]ASEM,Healthy aging,PET imaging,Alpha7 nicotinic acetylcholine receptor
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