Effects of the Gut-Liver Axis on Ischemia-Mediated Hepatocellular Carcinoma Recurrence in the Mouse Liver

L. Orci,S. Lacotte,V. Delaune,G. Oldani,F. Slits,C. Rossetti, L. Rubbia-Brandt,P. Morel,C. Toso

Journal of Hepatology（2017）

引用 55|浏览21

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摘要

•A mechanism is proposed whereby cancer recurrence is influenced by the gut–liver axis.•The mechanism relies on Toll-like receptor 4 activation by circulating endotoxin.•Remote preconditioning impedes this mechanism by preventing bacterial translocation.

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关键词

Hepatocellular carcinoma,Gut–liver axis,Ischemia-reperfusion,Remote ischemic preconditioning,Endotoxin,Toll-like receptor 4,Liver surgery

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