Comparative genome and phenotypic analysis of three Clostridioides difficile strains isolated from a single patient provide insight into multiple infection of C. difficile

Uwe Groß,Elzbieta Brzuszkiewicz,Katrin Gunka,Jessica Starke,Thomas Riedel,Boyke Bunk,Cathrin Spröer,Daniela Wetzel,Anja Poehlein,Cynthia Chibani,Wolfgang Bohne,Jörg Overmann,Ortrud Zimmermann,Rolf Daniel,Heiko Liesegang

BMC genomics（2018）

引用 364|浏览62

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摘要

Clostridioides difficile infections (CDI) have emerged over the past decade causing symptoms that range from mild, antibiotic-associated diarrhea (AAD) to life-threatening toxic megacolon. In this study, we describe a multiple and isochronal (mixed) CDI caused by the isolates DSM 27638, DSM 27639 and DSM 27640 that already initially showed different morphotypes on solid media.

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关键词

Clostridioides difficile,Clostridium difficile,Multiple infection,Genetic switch,Genomic adaptation,Horizontal gene transfer

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