Accessing chemical diversity from the uncultivated symbionts of small marine animals

Thomas E Smith,Christopher D Pond,Elizabeth Pierce,Zachary P Harmer,Jason Kwan,Malcolm M Zachariah,Mary Kay Harper,Thomas P Wyche,Teatulohi K Matainaho,Tim S Bugni,Louis R Barrows,Chris M Ireland,Eric W Schmidt

NATURE CHEMICAL BIOLOGY（2018）

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摘要

combination of spectroscopy, metagenomics, and synthetic biology enables the characterization of the antiviral divamides, a class of lanthipeptide natural products in which even minor changes in structure lead to different biological activities.

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关键词

Biosynthesis,Medicinal chemistry,Natural products,Chemistry/Food Science,general,Biochemical Engineering,Biochemistry,Cell Biology,Bioorganic Chemistry

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