Patchouli Alcohol protects against Ischemia/Reperfusion-induced brain injury via inhibiting neuroinflammation in normal and obese mice.

•As an anti-inflammatory drug, PA hasn’t been tested in ischemic stroke.•PA was evaluated in normal and obese mice with cerebral I/R injury.•PA reduced infarct volume, protected BBB function and decreased inflammatory makers.•PA protected against cerebral I/R injury probably by modulating MAPKs signaling.•PA can be a potential drug to translate for clinical use.