Loxosceles venom Sphingomyelinase D activates human blood leukocytes: Role of the complement system.

•We show here the role of complement system in the endotoxic-like shock triggered by L. intermedia venom and its SMase D.•Our data shows that complement system contributes to systemic inflammation observed in envenomation by Loxosceles spiders.•The therapeutic management of systemic Loxosceles envenomation could include the use complement inhibitors.