Cdkn2a deficiency promotes adipose tissue browning.

Nabil Rabhi,Sarah Anissa Hannou,Xavier Gromada,Elisabet Salas,Xi Yao,Frédérik Oger,Charlène Carney,Isabel C Lopez-Mejia,Emmanuelle Durand,Iandry Rabearivelo,Amélie Bonnefond,Emilie Caron,Lluis Fajas,Christian Dani,Philippe Froguel,Jean-Sébastien Annicotte

Molecular Metabolism（2018）

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摘要

•Cdkn2a deficiency protects mice against high fat diet-induced obesity.•Cdkn2a modulates brown-like/beige fat gene networks involved in energy production and lipid metabolism.•Increased CDKN2A expression in human obese adipocytes.•Increased UCP1 levels in adipocytes differentiated from CDKN2A-silenced hiPS cells.

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关键词

Obesity,Type 2 diabetes,Insulin sensitivity,Energy expenditure,cdkn2a,Genome-wide association study,Adipose tissue browning

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