No genetic association detected with mepolizumab efficacy in severe asthma.

Lynn Condreay,Mathias Chiano,Hector Ortega,Natalie Buchan,Elizabeth Harris,Eugene R Bleecker,Philip J Thompson,Marc Humbert,Peter Gibson,Steven Yancey,Soumitra Ghosh

Respiratory Medicine（2017）

引用 19|浏览51

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摘要

•Efficacy pharmacogenetics of mepolizumab treatment in patients with severe asthma was investigated.•A candidate polymorphism analysis and an unbiased genome-wide association analyses were performed.•No genetic effect on mepolizumab treatment response was identified.

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关键词

Severe asthma,Mepolizumab,Pharmacogenetics,Exacerbation

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