Characterization of early-onset motor deficits in the Pink1 -/- mouse model of Parkinson disease.

Cynthia A Kelm-Nelson, Alexander F L Brauer, Kelsey J Barth, Jacob M Lake, Mackenzie L K Sinnen,Forrest J Stehula,Cagla Muslu,Roberta Marongiu,Michael G Kaplitt,Michelle R Ciucci

Brain Research（2018）

引用 27|浏览2

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摘要

•Pink1−/− mice exhibit variations in simple call production and intensity.•Pink1−/− mice demonstrate reduced gross motor activity.•Pink1−/− mice show a slower locomotor activity time.•Pink1−/− mice do not have nigrostriatal dopamine loss at 6 months of age.

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关键词

Parkinson disease,Mouse,Ultrasonic vocalization,Pink1

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