Human vs. mouse nociceptors - similarities and differences.

•Comparative analysis of TrkA expressing nociceptors in human versus mouse dorsal rot ganglia.•Double fluorescence in situ hybridization to assess similarities and differences in sensory neurons of the two species.•The fractional abundance of TrkA positive neurons co-expressing specific receptors is different in rodents and humans.•Results have implications for translating data from rodent pain models to human pain pathologies.