Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy
NATURE(2017)
摘要
product of the soluble epoxide hydrolase enzyme, 19,20-dihydroxydocosapentaenoic acid (19,20-DHDP), is implicated in the pathogenesis of diabetic retinopathy; levels of 19,20-DHDP increase in the retinas of mice and humans with diabetes, and inhibition of its production can rescue vascular abnormalities in a mouse model of the disease.
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关键词
Chronic inflammation,Target identification,Science,Humanities and Social Sciences,multidisciplinary
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