Immunomodulatory effects of a rationally designed peptide mimetic of human IFNβ in EAE model of multiple sclerosis.

Mansour Poorebrahim,Matin Asghari,Mohammad Foad Abazari,Hassan Askari,Solmaz Sadeghi,Asghar Taheri-Kafrani,Mohammad Hossein Nasr-Esfahani,Pegah Ghoraeian,Maryam Nouri Aleagha,Seyed Shahriar Arab,Derek Kennedy,Alireza Montaseri,Mahsa Mehranfar,Nima Sanadgol

Progress in Neuro-Psychopharmacology and Biological Psychiatry（2018）

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摘要

The efficiency of interferon beta (IFNβ)-based drugs is considerably limited due to their undesirable properties, especially high immunogenicity. In this study, for the first time we investigated the impact of a computationally designed peptide mimetic of IFNβ, called MSPEP27, in the animal model of MS.

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关键词

Multiple sclerosis,IFNβ,Peptide,MSPEP27,EAE,Inflammation

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