Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice

Proceedings of the National Academy of Sciences of the United States of America, Volume 114, Issue 51, 2017.

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Keywords:
Alzheimer’s diseaseneurodegenerationprionselective vulnerabilitytau

Abstract:

Misfolding of tau proteins into prions and their propagation along neural circuits are thought to result in neurodegeneration causing Alzheimer's disease, progressive supranuclear palsy, chronic traumatic encephalopathy, and other tauopathies. Little is known about the molecular processes mediating tau prion replication and spreading in d...More

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