MeHg affects the activation of FAK, Src, Rac1 and Cdc42, critical proteins for cell movement in PDGF-stimulated SH-SY5Y neuroblastoma cells.

A José Alberto Hernández, V Liliana Reyes,Damaris Albores-García,Rocío Gómez,Emma S Calderón-Aranda

Toxicology（2018）

引用 10|浏览4

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摘要

•Low concentrations of MeHg inhibit PDGF-induced SH-SY5Y cell migration.•MeHg interferes PDGF-induced formation of lamellipodia and filopodia in SH-SY5Y cells.•MeHg disrupts the activation of the FAK and focal adhesion dynamic in SH-SY5Y cells.•MeHg affects activation of critical proteins for the regulation of cell movement.

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关键词

MeHg,Ca2+,Rac1,Cdc42,RhoA,GD,PND,FAK,p-FAKY397,Src,p-SrcY419,PDGF,PDGFr,EGFr,FERM,Y397,p130Cas,Dock180,ELMO1,Crk,GEF,Paxillin,PKL,β-PIX,FBS,MTT,DMSO,BSA,TRITC-phalloidin,CTCF,RIPA buffer,SDS,PAGE,PVDF,HRP,ANOVA,EC50,NGF,BDNF,Cys,ZF21,PTP-PEST,SHP-2,PTP-1

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