Constitutive MAP-kinase activation suppresses germline apoptosis in NTH-1 DNA glycosylase deficient C. elegans

Henok Kassahun,Tanima SenGupta,Alfonso Schiavi,Silvia Maglioni, Hanne K. Skjeldam,Katarzyna Arczewska, Nicole L. Brockway,Suzanne Estes,Lars Eide,Natascia Ventura,Hilde Nilsen

DNA Repair（2018）

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摘要

•nth-1 mutants show mitochondrial dysfunction and chronic oxidative stress.•nth-1 mutants have high basal activation of stress responsive kinases JNK-1 and PMK-1.•Attenuated apoptotic response to paraquat is a consequence of high basal MAPK activation.

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关键词

C. elegans,Base excision repair,NTH-1,Apoptosis,Oxidative stress

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